abstract：:Clinical studies have shown that moderately intense physical activity effectively treats various types of depression. Beneficial effects have been reported in the acute phase of the disease as well as in a long-term perspective. In addition, epidemiological studies have shown that inactivity increases the risk of depr...

journal_title：Medical hypotheses

authors： Stenman E,Lilja A

更新日期：2013-01-01 00:00:00

abstract：:In the recent hypothesis that hair loss might be a manifestation of metabolic abnormalities particularly hyperglicemia. It has been reported various environmental risk factors affecting hair loss. There is growing evidence on the relationship between prediabetes and worse metabolic profile. However, there are few stud...

journal_title：Medical hypotheses

authors： Cakir E

更新日期：2012-12-01 00:00:00

abstract：:Inflammatory bowel disease (IBD) is a chronic inflammatory disorder, with increasing incidence and prevalence in the last one-half century. IBD patients suffer from autonomic vagal neuropathy and nerve dysfunction, with deficiency of acetylcholine in inflamed mucosa. Recent studies showed that death of enteric neuron ...

journal_title：Medical hypotheses

authors： Guo Y,Lu N,Bai A

更新日期：2012-11-01 00:00:00

abstract：:Helical bundles are found in all the known structures of peanut allergens. The peptide fragments, which survive gastrointestinal digestion of the allergens and are absorbed intact, are hypothesized to reassociate and form stable helical bundles in the circulation, which could elicit a specific IgE response resulting i...

journal_title：Medical hypotheses

authors： Mikita CP,Padlan EA

更新日期：2012-11-01 00:00:00

abstract：:Myocardial ischemia/reperfusion injury (I/RI) is the principal cause of mortality and morbidity in diabetic patients undergoing cardiac surgery. However, there is no specific measure available to protect diabetic hearts in this clinical setting. Our clinical studies showed that adenosine pre-treatment or post-treatmen...

journal_title：Medical hypotheses

authors： Yang Y,Duan W,Zhou J,Yan J,Liu J,Zhang J,Jin Z,Yi D

更新日期：2012-10-01 00:00:00

abstract：:Curvilinear distraction is currently under investigation to reconstruct curved maxillofacial bone defects. However, previous studies have revealed the discrepancy between the contour of the regenerated bone in the distraction gap and the curvilinear pathway of the transport disc. We hypothesize that the discrepancy is...

journal_title：Medical hypotheses

authors： Zhou L,Shang H,Feng Z,Liu C,Ye W,Ma Q,Wu W,Liu Y

更新日期：2012-10-01 00:00:00

abstract：:Pulseless electrical activity occurs when organised or semi-organised electrical activity of the heart persists but the product of systemic vascular resistance and the increase in systemic arterial flow generated by the ejection of the left venticular stroke volume is not sufficient to produce a clinically detectable ...

journal_title：Medical hypotheses

authors： Hogan TS

更新日期：2012-10-01 00:00:00

abstract：:Gender differences in stem cell population have recently been identified. Blood and tissue samples from women showed consistent elevation of hematopoietic stem cell populations, mesenchymal stem cell populations and endothelial progenitor cells compared to men of similar ages. We and others have shown an increase in h...

journal_title：Medical hypotheses

authors： El-Badri NS,Groer M

更新日期：2012-10-01 00:00:00

abstract：:Long pentraxin 3 (PTX3) is a recently discovered multimeric inflammatory mediator that is structurally linked to short pentraxins, such as C-reactive protein (CRP) and serum amyloid P component. PTX3 is produced by a variety of tissues and cells, including vascular endothelial cells and macrophages. Because of its ext...

journal_title：Medical hypotheses

authors： Parlak A,Iyisoy A,Aydogan U,Cakir E,Saglam K

更新日期：2012-09-01 00:00:00

abstract：:Sepsis is a life-threatening disease requiring rapid diagnosis and treatment. Steroid hormones (e.g., estradiol, dehydroepiandosterone) have been suggested to reduce the hyper-inflammatory response of the immune system and to improve outcome in sepsis. We hypothesize that the impact of steroid hormones on the metaboli...

journal_title：Medical hypotheses

authors： Lehmann C,Sharawy N,Zhou J,Pavlovic D

更新日期：2012-09-01 00:00:00

abstract：UNLABELLED:Teeth start as bi-layered epithelial soft tissue follicles within bony jaws. Follicles grow into teeth and erupt. Early third molar follicles are detectable 8-9 years (±9 months). Intra-oral dental arches of jaws have finite space accommodating formed crowns. The last teeth to erupt are third molars. When th...

journal_title：Medical hypotheses

authors： Touyz LZ,Dent M

更新日期：2012-09-01 00:00:00

abstract：:Cancer cells have a greater need for energy and a ready supply of the building blocks necessary for the synthesis of macromolecules (nucleotides, protein, lipids) in order to duplicate genome and biomass. The hypothesis can be postulated that those precursors for synthetic processes, which can only be furnished by gly...

journal_title：Medical hypotheses

authors： Dell' Antone P

更新日期：2012-09-01 00:00:00

abstract：:Viral infections are often the etiological agents of severe acute and chronic human diseases. Their peculiar biology usually leads to the need of design specific therapies for each virus, and the eradication of the viruses and the healing of the patients very often are not reached also after decades of theoretical and...

journal_title：Medical hypotheses

authors： Arancio W

更新日期：2012-09-01 00:00:00

abstract：:This article has been withdrawn at the request of the author(s) and/or editor. The Publisher apologizes for any inconvenience this may cause. The full Elsevier Policy on Article Withdrawal can be found at http://www.elsevier.com/locate/withdrawalpolicy. ...

journal_title：Medical hypotheses

authors： Dillon SP,Kurien BT,Maier-Moore JS,Wiley GB,Gaffney PM,Scofield RH

更新日期：2012-08-20 00:00:00

abstract：:About 25-50% of children and adolescents with attention-deficit hyperactivity disorder (ADHD) experience sleep problems. An appropriate assessment and treatment of such problems might improve the quality of life in such patients and reduce both the severity of ADHD and the impairment it causes. According to data in th...

journal_title：Medical hypotheses

authors： Miano S,Parisi P,Villa MP

更新日期：2012-08-01 00:00:00

abstract：:The cumulative incidence of uterine leiomyoma at age 50 is ≈ 70% in White women and >80% in Black women. Although risk factor research is limited, increasing age, and being premenopausal, nulliparous or Black are risk factors for leiomyomas. Black women tend to have larger leiomyomas and be younger at diagnosis. Surpr...

journal_title：Medical hypotheses

authors： Wegienka G

更新日期：2012-08-01 00:00:00

abstract：:An observation of sleep improvement with vitamin D supplementation led to a 2 year uncontrolled trial of vitamin D supplementation in 1500 patients with neurologic complaints who also had evidence of abnormal sleep. Most patients had improvement in neurologic symptoms and sleep but only through maintaining a narrow ra...

journal_title：Medical hypotheses

authors： Gominak SC,Stumpf WE

更新日期：2012-08-01 00:00:00

abstract：:In plastic and reconstructive surgery, there is a tremendous clinical need for adequate implants are needed to restore soft-tissue defects resulting from tumor resection, traumatic injury, or congenital anomalies. Restoring the aesthetic function of the soft tissue is as important as restoring the natural tissue funct...

journal_title：Medical hypotheses

authors： Chang Q,Lu F

更新日期：2012-08-01 00:00:00

abstract：:Although Still's disease has been first described more than one century ago, it still appears as an orphan entity, which should be separated from the other auto-inflammatory diseases (AID). The main reason to individualize Still's disease among the AID is the absence of any genetic predisposition. Recently, the human ...

journal_title：Medical hypotheses

authors： Hayem F,Hayem G

更新日期：2012-08-01 00:00:00

abstract：:Muscle spindles are increasingly recognized as playing a pivotal role in the cause of dystonia. This development and own laryngeal observations that support the idea of causally "well-intentioned" stuttering motivated us to present the following hypothesis: stuttering events compensate for a sensory problem that arise...

journal_title：Medical hypotheses

authors： Schuster SH,Schuster FM

更新日期：2012-07-01 00:00:00

abstract：:Preeclampsia (PE) and gestational diabetes mellitus (GDM) are two of the most common medical complications of pregnancy, with risks for both mother and child. Like many other antepartum complications, PE and GDM occur only in pregnancy. However, it is not clear if pregnancy itself is the cause of these complications o...

journal_title：Medical hypotheses

authors： Wen SW,Xie RH,Tan H,Walker MC,Smith GN,Retnakaran R

更新日期：2012-07-01 00:00:00

abstract：:Inflammation integrates diverse mechanisms that are associated not only with pathological conditions, such as cardiovascular diseases, type 2 diabetes, obesity, neurodegenerative diseases and cancer, but also with physiological processes like reproduction i.e. oogenesis and embryogenesis as well as aging. In the curre...

journal_title：Medical hypotheses

authors： Aller MA,Arias N,Fuentes-Julian S,Blazquez-Martinez A,Argudo S,Miguel MP,Arias JL,Arias J

更新日期：2012-06-01 00:00:00

abstract：BACKGROUND:Somatization is a multisomatoform disorder characterized by medically unexplained, functional or psychosomatic symptoms. Similar somatic symptoms are key components of depression and Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS). METHODS:This paper reviews the evidence that such symptoms are o...

journal_title：Medical hypotheses

authors： Anderson G,Maes M,Berk M

更新日期：2012-06-01 00:00:00

abstract：:A bi-directional association between mood disorders and migraine has been consistently reported. Nevertheless, the neurobiological substrate underlying the association between these disorders remains unknown. In the article herein we review evidence for the role of inflammatory cytokines in the neurobiology of bipolar...

journal_title：Medical hypotheses

authors： Brietzke E,Mansur RB,Grassi-Oliveira R,Soczynska JK,McIntyre RS

更新日期：2012-05-01 00:00:00

abstract：:We describe a new term: glutamate-based depression (GBD). GBD is defined as a chronic depressive illness associated with environmental stress and diseases associated with altered glutamate neurotransmission. We hypothesize that glutamate-induced over-activation of extrasynaptic NMDA receptors in the subgenual cingulat...

journal_title：Medical hypotheses

authors： McCarthy DJ,Alexander R,Smith MA,Pathak S,Kanes S,Lee CM,Sanacora G

更新日期：2012-05-01 00:00:00

abstract：:Pyoderma gangrenosum (PG) is a rare dermatological condition belonging to the group of deep neutrophilic dermatoses. It can display a protracted and refractory course. The list of treatments which have been tried and proved their efficacy is long, but none of them provide constant efficacy. In the absence of gold stan...

journal_title：Medical hypotheses

authors： Kluger N

更新日期：2012-05-01 00:00:00

abstract：:Anorexia nervosa manifests a wide range of features which cannot fully be explained on the basis of socio-cultural pressures to be thin, nor by starvation, nor dehydration. Evidence is emerging of a significant neurobiological contribution to its aetiology. However there has to date been no explanation for its pathoge...

journal_title：Medical hypotheses

authors： Nunn K,Frampton I,Lask B

更新日期：2012-05-01 00:00:00

abstract：:Osteosarcoma is the most common primary malignant tumor of bone. Except for the improvement in five-year survival achieved by the adoption of neoadjuvant chemotherapy strategy, there are nearly no improvement for the treatment of osteosarcoma in the past 30 years, especially for the patients with metastatic disease. I...

journal_title：Medical hypotheses

authors： Weibo P,Zhaoming Y

更新日期：2012-05-01 00:00:00

abstract：:Encouraging results have been obtained with stereotactic body radiation therapy (SBRT) for early stage non-small cell lung cancer (NSCLC). However, local control rates decrease in larger volume disease. Several studies have found a correlation between T stage or tumor volume and local progression-free survival. In man...

journal_title：Medical hypotheses

authors： Nieder C,Andratschke N

更新日期：2012-04-01 00:00:00

abstract：:Autism is a complex and heterogeneous neurodevelopmental disorder of unknown etiology but very likely resulting from both genetic and environmental factors. Recent estimates suggest that it affects 1 in 100-150 individuals in the US. Oxidative stress, inflammation and mitochondrial dysfunction have all been suggested ...

journal_title：Medical hypotheses

authors： Maher P

更新日期：2012-04-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) therapy has emerged as a potent therapeutic strategy to improve myocardial infarction. However MSCs therapy encounters a few obstacles regarding the poor viability of the transplanted cells. Therefore, it is important to explore a strategy to enhance post-transplanted MSC viability. To ov...

journal_title：Medical hypotheses

authors： Sharifi AM,Mottaghi S

更新日期：2012-04-01 00:00:00

abstract：:Radiotherapy (RT) has been established to improve both local control as well as overall survival rates in breast cancer. However, RT especially in left-sided breast cancer also irradiates a portion of the heart. Radiation associated toxicity to the heart assumes significance because of improval in survival of breast c...

journal_title：Medical hypotheses

authors： Gupta D,Shukla P,Munshi A,Aggarwal JP

更新日期：2012-03-01 00:00:00

abstract：:Triggering receptor expressed on myeloid cells-1 (TREM-1) is a recently identified cell surface receptor that is expressed mainly on monocytes and neutrophils, and plays an important role as an amplifier of inflammatory response in acute and chronic inflammatory conditions. Recent studies suggested that TREM-1 contrib...

journal_title：Medical hypotheses

authors： Kim TH,Choi SJ,Lee YH,Song GG,Ji JD

更新日期：2012-02-01 00:00:00

abstract：:In endemic pemphigus foliaceus (EPF) or "fogo selvagem" the epidemiological evidence shows that all the described outbreaks occur on the banks of rivers where there is mercury contamination from alluvium gold mining and deforestation. Pathophysiological evidence shows a similarity to pemphigus induced by sulphydryl (S...

journal_title：Medical hypotheses

authors： Robledo MA

更新日期：2012-01-01 00:00:00

abstract：:The autoimmune disease rheumatoid arthritis (RA) presents difficulty in diagnosis, commonly observed flare ups, polycyclical nature of RA progression, and variable response to therapies. Congruent with multiple causes, literature has documented various infectious agents, environmental factors, physical trauma, silica ...

journal_title：Medical hypotheses

authors： Molnar-Kimber KL,Kimber CT

更新日期：2012-01-01 00:00:00

abstract：:The hypothesis of the evolutionary origin of bipolar disorder (EOBD) synthesized ideas about the biological clock and seasonal shifts in mood (Rosenthal, Wehr) with theorizing that bipolar disorder descends from a pyknic (compact, cold-adapted) group (Kretchmer). The hypothesis suggested that bipolar behaviors evolved...

journal_title：Medical hypotheses

authors： Sherman JA

更新日期：2012-01-01 00:00:00

abstract：:The first conjugate vaccine was approved for use in the US in 1988 to protect infants and young children against the capsular bacteria Haemophilus influenzae type b (Hib). Since its introduction in the US, this vaccine has been approved in most developed countries, including Denmark and Israel where the vaccine was ad...

journal_title：Medical hypotheses

authors： Richmand BJ

更新日期：2011-12-01 00:00:00

abstract：:Deep brain stimulation of the pedunculopontine tegmental nucleus (PPTg) had usually been reported to improve the symptoms of advanced Parkinson's disease. Previous studies showed that neurons in the PPTg involved in the control of the sympathetic outflow to the kidneys. Our recent studies using transneuronal labeling ...

journal_title：Medical hypotheses

authors： Xiang HB,Liu C,Guo QQ,Li RC,Ye DW

更新日期：2011-12-01 00:00:00

abstract：:An unexpected and novel finding is described and discussed here concerning the synaptic physiology of hippocampal slices during the period of recovery after brain dissection. Contrary to the common notion that the amplitude of synaptic responses recovers in a single exponential rising fashion, we found that synaptic r...

journal_title：Medical hypotheses

authors： Gourov AV

更新日期：2011-12-01 00:00:00

abstract：:The blockage of a vena cava filter (VCF) by the captured blood clots presents a serious problem to the patients. Commercially available cone-shaped VCFs such as the Gunther Tulip filter has an inherent structural flaw that leads the captured blood clots to be trapped in their front spire areas where the flow-induced s...

journal_title：Medical hypotheses

authors： Chen Z,Fan Y,Deng X

更新日期：2011-12-01 00:00:00